1472 Cathelicidin has multifunctional roles in pathogenesis of scleroderma and dermatomyositis

LL-37, an active form of human cathelicidin exhibits various effects on immunity and inflammation, such as induction inflammatory cells angiogenesis in addition to its antimicrobial activity. Involvement LL-37 the pathogenesis several skin diseases psoriasis rosacea has been described. To search for association other diseases, we focused scleroderma dermatomyositis. Previously, it shown that is increased scleroderma, mainly dermal small vessels fibroblasts, less reported lesions We examined expression lesional patients with dermatomyositis using immunohistochemical staining. Compared healthy controls, showed especially vessels, previously reported. In dermatomyositis, was expressed infiltrating neutrophils well whole epidermis except stratum corneum. Subcutaneous administration wild-type mice caused vasodilation, edema, cell infiltration from dermis subcutis, necrosis muscle tissue. Furthermore, analyzed Cramp, murine orthologue angiogenesis, vascular permeability, inflammation fibrosis a mouse model bleomycin interfering RNA (siRNA) against Cramp. this report, differential localization explored role scleroderma.